Trudy Fischer was born in 1917 in Basel, Switzerland. She studied there from 1948 to 1950 before coming to Canada, where she completed further studies in Montreal with Arthur Lismer and Marion Scott (1951), as well as in Saskatoon at the University of Saskatchewan with Eli Bornstein and at the University of Regina with Kenneth Lochhead and Arthur McKay. In addition to her own artistic practice, Fischer worked as a part-time librarian at Saskatoon's Normal School and an art instructor at the Saskatoon Art Centre and the School for the Deaf.
In 1956, Fischer received a Canada Council grant for her research in art education for people with disabilities.
Fischer's work includes serigraphs and paintings in oils, watercolours, and pen and ink. Her work is in the collection of the Saskatchewan Arts Board.